Alnylam Pharmaceuticals

Jun 22, 2026

Cyber Defense Principal Engineer

HybridUnited States

Cambridge, Massachusetts, United States

PythonGo

Overview

Alnylam is pioneering RNAi therapeutics and scaling rapidly across research, development, and global commercialization. The

Director, Cyber Defense Principal Engineer will play a critical role in designing and advancing our next-generation cyber defense capabilities, shaping how we detect, investigate, and respond to threats at scale.

Reporting to the Senior Director, Cyber Defense, this senior individual contributor will define and execute the technical strategy to modernize and future-proof Alnylam’s security platforms. This role will lead the evolution of cyber operations technology, build scalable solutions, and drive enterprise-wide initiatives that strengthen the security and resilience of our systems and data.

This is a hybrid position, primarily based in Cambridge, MA and includes participation in an on-call rotation, with flexibility to support incident response outside standard business hours, as needed.

#LI-MH1 #LI-Hybrid

U.S. Pay Range

$199,800.00 - $270,300.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Define and execute the long-term strategy and technical roadmap for Alnylam’s cyber defense capabilities.

Architect and scale core security platforms, including SIEM/SOAR, security data pipelines, automation frameworks, and detection infrastructure.

Lead enterprise detection engineering, delivering advanced analytics and risk-based alerting across cloud, endpoint, identity, network, and SaaS environments.

Build and integrate a unified cyber defense platform to enhance visibility, automation, and enterprise resilience.

Establish scalable security standards, architectures, and operating principles across Cyber Defense and enterprise teams.

Drive an engineering-first approach to detection and response, leveraging automation, AI-enabled workflows, and data-driven decision making.

Serve as a senior technical advisor to leadership on cyber defense strategy, complex incident response, and enterprise risk.

Qualifications

10+ years of experience across core cyber defense disciplines (e.g., security engineering, detection engineering, threat hunting, incident response, vulnerability management, offensive security)

Strong programming and automation skills (e.g., Python, Go), with experience building custom security tooling, integrations, and detections

Proven experience leading large-scale SIEM migrations or enterprise security platform transformations

Deep expertise across modern security technologies (e.g., SIEM, SOAR, EDR/XDR, threat intelligence platforms, cloud security, and security data platforms)

Hands-on experience applying AI/ML and automation to improve threat detection, investigation workflows, and incident response

Advanced detection engineering capabilities, including behavioral analytics, threat hunting, and frameworks such as MITRE ATT&CK

Experience designing or supporting insider threat and advanced monitoring programs

Strong knowledge of vulnerability management, exposure reduction, and risk-based prioritization

Excellent communication and influencing skills, with the ability to partner across engineering, infrastructure, legal, compliance, and business leadership teams

Experience operating in complex, global enterprise environments

Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: alnylam.com/careers

About Alnylam

We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

Languages

Cyber Defense Principal Engineer

Overview

U.S. Pay Range

Responsibilities

Qualifications

About Alnylam

Show your skills.Get discovered.

More opportunities with one profile

Keep exploring

Solution Architect - *Hybrid

Database Engineer

Support Operations Specialist